Relationship Between Stress and Saliva Biomarkers in Breast Cancer Patients Receiving Outpatient Chemotherapy


Breast cancer is the first of the cancer incidence in women is common age more increased by westernization of eating habits. The 30 's - 50' s, the predilection age of breast cancer, live with many roles and responsibilities in the company and at home, and it is a period of stressful diversity.A physiologically active substance which changes at present depending on the stress state is expected to be used as an objective physiological biomarker of a human stress state. It has been reported that salivary α-amylase and cortisol are useful tools to take stable values in normal times and investigate the effects of stress.This study aimed to clarify whether mood / emotion of a cancer patient undergoing chemotherapy is related to biomarkers in saliva and can be utilized as an index reflecting stress of a patient receiving chemotherapy will be examined.Five breast cancer patients being treated by outpatients chemotherapy were recruited.A questionnaire was used to survey the attributes, and level of stress in these patients based on the POMS2(Profile of Mood States 2nd Edition). Salivary cortisol and salivary α - amylase were measured as salivary biomarkers. Patients’ mean age was 53.4 years.There were one subject with a strong negative emotional state and four on average. Salivary cortisol, salivary α - amylase results could not be associated with POMS2. It is necessary to increase the number of subjects in the future and study them.

Author Information
Saori Tamura, School of Nursing, Doshisha Women’s College of Liberal Arts, Japan
Yuka Hayama, School of Nursing, Doshisha Women’s College of Liberal Arts, Jersey
Sachiko Mitsuki, School of Nursing, Doshisha Women’s College of Liberal Arts, Japan
Ryuya Yamanaka, Graduate School of Nursing for Health Care Science, Kyoto Prefectural University of Medicine, Japan
Koichi Sakaguchi, Kyoto Prefectural University of Medicine, Japan

Paper Information
Conference: ACP2018
Stream: Mental Health

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Posted by James Alexander Gordon