Pain is the body’s alarm system and is triggered in the nervous system. It signals when something in the biosystem is going wrong. It has varied characteristics dependent on the individual and the circumstances. The Musa paradisiaca (L.) family Musaceae, commonly known as banana in English, is a perennial tree like herb grown indigenously in tropics and subtropics and also cultivated commercially in India for its fruits. The general objective of this research was to assess the potential analgesic activity of M. paradisiaca Linn peels. The peels are considered wastes and will prove cost effective should it be proven to contain analgesic properties. Two methods were used for the evaluation of analgesic activity namely; Hot Plate Method and Tail Immersion Method. Results revealed that there was a significant difference between the effects of the aqueous extract of M.paradisiaca L.(100 mg/kg and 200 mg/kg), and Morphine (p<0.05). In contrast with the Vehicle as negative control, the extract with a dose of 200mg/kg showed statistically significant difference in the results of the tests used for analgesic property. Only the aqueous extract having a dose of 200mg/kg then possesses analgesic activity, higher than the negative control but lower than morphine. The effect of time interval on the analgesic effects of the 200mg/kg extract and morphine showed varying results with the Hot Plate and the tail Immersion Method. Isolation and purification of the active constituent from the sample that elicits analgesia will refine the pharmacologic activity of M. paradisiaca Linn peels.
Rommel John Reyes, Emilio Aguinaldo College, Philippines
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