Author Information
Nino Rachvelishvili, Grigol Robakidze University, GeorgiaAisel Ajalieva-Akhverdova, Grigol Robakidze University, Georgia
Abstract
Historically, researchers have treated gastrointestinal (GI) health and psychological Well-being as separate fields. Currently, however, the Microbiota-Gut-Brain Axis (MGBA) occupies the forefront of biomedical research. This bidirectional communication network links the central nervous system (CNS), the enteric nervous system (ENS), the hypothalamic-pituitary-adrenal (HPA) axis, and our immune defenses. Recent literature (2024–2025) demonstrates that GI dysfunction and microbial imbalances (dysbiosis) directly drive the underlying biology of stress, anxiety, and Major Depressive Disorder (MDD). Functionally, the gut microbiome operates as a supplementary endocrine organ. It facilitates the synthesis of crucial neurotransmitters like serotonin, GABA, and dopamine, while also managing immune responses through cytokines and producing neuroactive short-chain fatty acids (SCFAs). This review synthesizes contemporary evidence on how the MGBA operates across neurochemical, immune, and psychosocial levels. Furthermore, it critically evaluates practical clinical interventions, including psychobiotics, dietary modulation, Fecal Microbiota Transplantation (FMT), and Cognitive Behavioral Therapy (CBT). Elucidating these precise mechanisms establishes a robust foundation for treating mental health through personalized, integrative medicine.
Paper Information
Conference: ACP2026Stream: Mental Health
This paper is part of the ACP2026 Conference Proceedings (View)
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To cite this article:
Rachvelishvili N., & Ajalieva-Akhverdova A. (2026) Emotional Well-being: Mechanistic Insights and Clinical Implications of the Gut-Brain Axis ISSN: 2187-4743 – The Asian Conference on Psychology & the Behavioral Sciences 2026 Official Conference Proceedings (pp. 153-160) https://doi.org/10.22492/issn.2187-4743.2026.14
To link to this article: https://doi.org/10.22492/issn.2187-4743.2026.14
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